Chemotherapeutic Loaded Dynamic Aggregated Albumin Nanoparticles for Lung Cancer Therapy

Abstract

The development of safe and effective anticancer drugs remains a significant challenge for the scientific community. A broad range of chemotherapeutic agents has been extensively evaluated for their efficacy across various patient populations. Among them, Epirubicin has demonstrated strong anti-cancer potential across different tumor models. In this study, Epirubicin-loaded Bovine Serum Albumin nanoparticles (EPI@BSA) were prepared using the desolvation method to explore their potential in lung cancer therapy. Physicochemical characterization confirmed that the nanoparticles were spherical and highly monodispersed. Cytotoxicity testing on the A549 cell line revealed enhanced cell death with the nanoparticle formulation compared to the free drug. Furthermore, semi-quantitative RT-PCR analysis indicated that the nanoparticles effectively induced apoptosis. These findings support the potential of a protein-based biodegradable carrier system to enhance the therapeutic efficacy of Epirubicin in cancer treatment.