Harnessing the power of copper-based metal–organic framework (HKUST-1) nanostructures for advanced wound healing

Abstract

This review explores the potential of copper-based metal–organic frameworks (MOFs), particularly HKUST-1 (Hong Kong University of Science and Technology-1), as an innovative solution for advanced wound healing. Wound healing is a multifaceted process involving antimicrobial defense, inflammation control, and tissue regeneration, areas where copper ions play a vital role. HKUST-1, a porous, crystalline MOF with copper as its core component, offers unique structural properties that enhance its utility in biomedical applications. This review delves into the biocompatibility of HKUST-1, its ability to release copper ions in a controlled manner, and its antimicrobial and pro-regenerative effects on wound healing. We further analyze the potential benefits of incorporating HKUST-1 into wound care products, such as dressings, gels, and drug delivery systems, while also addressing challenges like stability under physiological conditions, potential toxicity, and scalability issues. Finally, this review discusses the prospects for translating HKUST-1-based nanostructures into clinical practice, aiming for improved patient outcomes and faster wound healing.