From the journal:

Chemical Communications

A CRISPR Cas protein coronated AuNP nanostructure for enhanced uptake efficiency into cells

Zhaojia Deng,†ac   Rui Sha,†a   Hua Qin,ab   Yingxu Shang,ac   Aijiao Yuan,ac   Wenjing Xieac  and  Hanyong Peng ORCID logo *ac  

* Corresponding authors

a State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China
E-mail: hypeng@rcees.ac.cn

b College of Science, Northeastern University, Shenyang 110819, China

c University of Chinese Academy of Sciences, Beijing 100049, China

Abstract

The effectiveness of nanotechnologies is often limited by their non-specific aggregation in biological environments. We developed a protein coronated nanostructure by functionalizing AuNPs with nucleic acid scaffolds and CRISPR Cas proteins, significantly enhancing nanoparticle stability and cellular uptake efficiency, making it a promising tool for imaging and biomedical applications.

Graphical abstract: A CRISPR Cas protein coronated AuNP nanostructure for enhanced uptake efficiency into cells

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Article information

DOI
https://doi.org/10.1039/D5CC03658E
Article type
Communication
Submitted
01 Jul 2025
Accepted
20 Aug 2025
First published
21 Aug 2025
This article is Open Access
Creative Commons BY-NC license

Chem. Commun., 2025, Advance Article

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A CRISPR Cas protein coronated AuNP nanostructure for enhanced uptake efficiency into cells

Z. Deng, R. Sha, H. Qin, Y. Shang, A. Yuan, W. Xie and H. Peng, Chem. Commun., 2025, Advance Article , DOI: 10.1039/D5CC03658E

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