From the journal:

Chemical Communications

Enzyme inhibition-enabled CRISPR/Cas12a biosensing system for heparin-related non-nucleic acid biomarkers

Ruo Ma,   Wenjiao Fan,   Yueran Wang,   Xinrui Fei  and  Chenghui Liu  

Abstract

Different from conventional CRISPR/Cas12a systems that must employ sophisticated functional nucleic acids, protein switch or allosteric transcription factors (aTFs)-based signal conversion for non-nucleic acid analysis, this work realizes more facile non-nucleic acid biomarker quantification through a new heparin-mediated Cas12a inhibition route.

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Article information

DOI
https://doi.org/10.1039/D5CC03376D
Article type
Communication
Submitted
14 Jun 2025
Accepted
24 Jul 2025
First published
24 Jul 2025

Chem. Commun., 2025, Accepted Manuscript

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Enzyme inhibition-enabled CRISPR/Cas12a biosensing system for heparin-related non-nucleic acid biomarkers

R. Ma, W. Fan, Y. Wang, X. Fei and C. Liu, Chem. Commun., 2025, Accepted Manuscript , DOI: 10.1039/D5CC03376D

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