A modular, nanoscale platform for the targeted delivery of camptothecin to cancer cells expressing TAG-72

Reham Hassan; Zirui Zhu; Mingyang Ji; Ziyuan Meng; Emily R. Matas; Damu Sunilkumar; Dario Palmieri; Benjamin A. Conrad; Thomas J. Magliery; Jon R. Parquette

doi:10.1039/D5BM00788G

A modular, nanoscale platform for the targeted delivery of camptothecin to cancer cells expressing TAG-72

Reham Hassan,

^a Zirui Zhu,

^a Mingyang Ji,^a Ziyuan Meng,^a Emily R. Matas,^a Damu Sunilkumar,^b Dario Palmieri,^b Benjamin A. Conrad,

^a Thomas J. Magliery

*^a and Jon R. Parquette

*^a

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* Corresponding authors

^a Department of Chemistry and Biochemistry, The Ohio State University, 100 W. 18th Ave., Columbus, Ohio 43210, USA
E-mail: parquette.1@osu.edu, magliery.1@osu.edu

^b A Department of Cancer Biology and Genetics, The Ohio State University, Wexner Medical Center and The James Comprehensive Cancer Center, 460 W. 12th Avenue, Columbus, OH, USA

Abstract

A camptothecin (CPT)-dilysine nanotube, stabilized with a layer of polydopamine (PDA), was functionalized on the surface with anti-TAG-72 antibody fragments. Cell viability studies showed that the presence of the targeting anti-TAG-72 scFv significantly enhanced cytotoxicity against TAG-72 positive, LS-174T colon cancer cells, compared with HT-29 cells negative for the antigen.

This article is part of the themed collections: Materials Developments in Cancer Therapeutics and Biomaterials Science Open Access Spotlight

Biomaterials Science

A modular, nanoscale platform for the targeted delivery of camptothecin to cancer cells expressing TAG-72

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A modular, nanoscale platform for the targeted delivery of camptothecin to cancer cells expressing TAG-72

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