Kotaro Kikushima, Kohei Yamada, Narumi Umekawa, Natsumi Yoshio, Yasuyuki Kita and Toshifumi Dohi
Green Chem., 2023,25, 1790-1796
DOI:
10.1039/D2GC04445E,
Communication
Catalyst-free access to aryldifluoromethyl ketones has been achieved through decarboxylative arylation of α,α-difluoro-β-ketoacid salts using diaryliodonium(III) salts. The products were successfully transformed into the corresponding esters, amides, and difluoromethyl compounds. This strategy provides access to fluorine-containing drugs, thus contributing to drug design.
