Development of regiodivergent asymmetric reductive coupling reactions of allenamides to access heteroatom-rich organic compounds

Abstract

Organic compounds of biological importance often contain multiple stereogenic C-heteroatom functional groups (e.g. amines, alcohols, and ethers). As a result, synthetic methods to access such compounds in a reliable and stereoselective fashion are important. In this feature article, we present a strategy to enable the introduction of multiple C-heteroatom functional groups in a regiodivergent cross-coupling approach through the use of reductive coupling chemistry employing allenamides. Such processes allow for opportunities to access different heteroatom substitution patterns from the same starting materials.