Jian Xiao, Jun Zhao, Ya-Wen Wang, Gan Luo and Yu Peng
Org. Biomol. Chem., 2021,19, 9840-9843
DOI:
10.1039/D1OB02055B,
Communication
The first total synthesis of (+)-adunctin C (ent-1) and (+)-adunctin D (2), two monoterpene-substitued dihydrochalcones isolated from Piper aduncum (Piperaceae), was achieved. A regioselective oxidative [3 + 2] cycloaddition of acylphloroglucinol with (−)-β-phellandrene was developed to construct their unique spirobenzofuran skeleton. The absolute configurations of natural adunctins 1 and 2 were thus assigned through these endeavors.
