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Using light as an external stimulus plays a key role not only in modulating activities of nanozymes, but also in constructing efficient biosensing systems. This mini-review highlights recent advances in light-responsive nanozyme-based biosensing systems. First, we introduce the light stimulation for regulating nanozymes’ activities. Then, several strategies are presented to construct efficient photo-responsive nanozyme-based detection systems by using metal-based nanozymes, carbon-based nanozymes, and MOF-based nanozymes, respectively. Moreover, the detection mechanisms of current biosensors are discussed. Finally, we discuss the current challenges and future perspectives of this research area.

Graphical abstract: Light-responsive nanozymes for biosensing

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