Zhonglei Wang and Liansuo Zu
Chem. Commun., 2019,55, 5171-5174
DOI:
10.1039/C9CC01833F,
Communication
The organocatalytic enantioselective Friedel–Crafts alkylation of phloroglucinol derivatives with enals is reported, providing general access to the benzylic chiral centers shown in a variety of phloroglucinol natural products. The synthetic utility is demonstrated by the very concise asymmetric total synthesis of aflatoxins B2.
