Vivek Sharma, Anmolpreet Kaur, Subash Chandra Sahoo and Swapandeep Singh Chimni
Org. Biomol. Chem., 2018,16, 6470-6478
DOI:
10.1039/C8OB01588K,
Paper
The bifunctional nature of the cinchonidine squaramides has been successfully employed to catalyze the enantioselective 1,4-Michael addition reaction of pyrazolin-5-ones with 2-enoylpyridines under mild reaction conditions. Through this methodology, a broad range of optically active heterocyclic derivatives bearing both pyrazole and pyridine motifs have been synthesized in yields up to 88% and enantiomeric excess up to 96%.
