Jun Ueda, Shingo Harada, Hiroki Nakayama and Tetsuhiro Nemoto
Org. Biomol. Chem., 2018,16, 4675-4682
DOI:
10.1039/C8OB00894A,
Paper
A simple protocol to directly access γ-amino acid derivatives by intermolecular regioselective hydroamination of trichloroethyl alkenyldiazoacetates with carbamate using a silver tetrafluoroborate catalyst is described. Density functional theory (DFT) calculations to analyze the reaction mechanism revealed that multiple attractive interactions occur in a transition state to promote the vinylogous addition of nitrogen nucleophiles.
