Subhajit Bhunia, Saikat Chaudhuri, Subhadip De, K. Naresh Babu and Alakesh Bisai
Org. Biomol. Chem., 2018,16, 2427-2437
DOI:
10.1039/C7OB03069J,
Paper
The synthesis of the tetracyclic skeleton of ergot alkaloids has been developed via a key organocatalytic enantioselective aldol reaction using paraformaldehyde as the C1-unit in the presence of thiourea catalyst followed by a key Pd-catalyzed directed coupling accelerated by the DavePhos ligand. Utilizing the aforementioned strategy, we have synthesized a key tetracyclic intermediate in up to 95% ee with high yield.
