Pd(II)-catalyzed β-C–H arylation of O-methyl ketoximes with iodoarenes

A Pd(II)-catalyzed selective β-arylation of O-methyl ketoximes was developed using iodoarenes as the coupling partners. This transformation has good functional group compatibility and can serve as a powerful synthetic tool for late-stage C–H arylation of complex compounds. Moreover, when employing 2-iodobenzoic acids as the substrates in this developed catalytic system, a type of unexpected five-membered lactones could be formed by tandem sp³ C–H arylation and oxygenation.