Probing the molecular mechanism of cerium oxide nanoparticles in protecting against the neuronal cytotoxicity of Aβ_1–42 with copper ions

The molecular mechanism of CeONP in protecting against neuronal cytotoxicity from amyloid peptides and copper ions was investigated systematically by photoluminescence of [Ru(phen)₂dppz]²⁺, morphology of TEM, mass spectroscopy, cell viability assay, ROS fluorescence assay, and EPR. The results revealed that CeONPs reduced Aβ_1–42 aggregation, protected from neurotoxicity of ROS induced by Cu²⁺ + Aβ_1–42via blocking the production of free radicals and scavenging the radicals with Ce³⁺/Ce⁴⁺ catalytic cycles, which provides a valuable insight into CeONPs as a therapeutic intervention in oxidative damage in Alzheimer's disease.