Alexandre Vasseur, Lionel Perrin, Odile Eisenstein and Ilan Marek
Chem. Sci., 2015,6, 2770-2776
DOI:
10.1039/C5SC00445D,
Edge Article
Remote functionalization of hydrocarbons could be achieved through successive zirconocene-mediated allylic C–H bond activations followed by a selective C–C bond cleavage. Determination of the reaction mechanism by density functional theory (DFT) calculations shows that the high stereocontrol observed in this process results from a large number of energetically accessible equilibria feeding a preferred reactive channel that leads to the major product. A distinctive consequence of this pattern is that stereoselectivity is enhanced upon heating.