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The highly regioselective aerobic oxidative cyclization of aromatic, heteroaromatic and alkenyl acids with alkynes in the presence of catalytic amounts of [{RuCl2(p-cymene)}2], AgSbF6 and Cu(OAc)2·H2O providing isocoumarin derivatives was investigated.

Graphical abstract: Regioselective synthesis of isocoumarins by ruthenium-catalyzed aerobic oxidative cyclization of aromatic acids with alkynes

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