The first chiral synthesis of (–)-oncinotine 1 in natural form has been achieved starting from the protected (S)-N-benzyloxycarbonyl-2-piperidylacetaldehyde 3 based on a new route involving 17-membered ring formation via iminium cyclization, which establishes the 17R absolute configuration of natural 1.
H. Ina, M. Ito and C. Kibayashi, J. Chem. Soc., Chem. Commun., 1995, 1015 DOI: 10.1039/C39950001015
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