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A two-dimensional porphyrin-MOF nanolayer was developed to construct an electrochemical aptasensor for monitoring oxytetracycline from 0.01 pg mL−1 to 0.1 ng mL−1. This aptasensor exhibited high sensitivity, outstanding selectivity, good stability, fine reproducibility, and quantitative detection ability in real samples.

Graphical abstract: Monitoring of trace oxytetracycline using a porphyrin-MOF layer-based electrochemical aptasensor

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