Correction: Surface enhanced Raman scattering for the multiplexed detection of pathogenic microorganisms: towards point-of-use applications

Abstract

Correction for ‘Surface enhanced Raman scattering for the multiplexed detection of pathogenic microorganisms: towards point-of-use applications’ by Matthew E. Berry et al., Analyst, 2021, DOI: 10.1039/D1AN00865J.

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The authors regret that an incorrect version of Table 1 was included in the original article. The correct version of Table 1 is presented below.

Table 1 A summary of the general approaches and studies discussed within this review

SERS approach	Summary	Performance
(1) Label-free detection	• SERS substrates for the capture of pathogens.	• Detection of three Gram negative bacterial strains (LOD 10^5 CFU mL^−1).^50
	• Intrinsic vibrational fingerprint of pathogens detected (no Raman reporters used).	• Detection of E. coli and S. aureus in tap water and milk (LOD 10^3 CFU mL^−1, 10 min).^51
		• Detection of multiple bacterial strains (LOD 1 CFU mL^−1, 5 min).^52
		• Detection of bacterial strains in mung bean sprouts (LOD 10^2 CFU mL^−1, 4 hours).^53
		• Sampling and detection of bacterial pathogens from skin wound (LOD 10^6 CFU mL^−1, 8 hours (5 min for sampling)).^99
		• Detection of meningitis pathogens in clinical CSF.^103
(2) Microfluidics	• Sample preparation, reaction, separation and detection integrated into a single device.	• Label-free detection of E. coli and S. aureus in blood (LOD 10^5 CFU mL^−1, 100 CFU mL^−1 in culture).^57
	• Supports label-free and label-based detection.	• Label-free detection of three bacterial strains in serum (LOD 4 CFU mL^−1, 15 min).^59
		• Label-based detection of S. enterica and N. lactamica using DEP enrichment (LOD 70 CFU mL^−1, 10 min).^61
		• Label-based detection of three bacterial pathogens at millilitre scale in blood (LOD <100 CFU mL^−1, 13 min).^63
		• Label-based detection of E. coli using DEP enrichment (LOD 1 CFU mL^−1).^65
		• Detection of eight foodborne pathogens.^98
		• Label-free detection of multiple viral strains in clinical nasopharyngeal swabs.^106
(3) Nucleic acid-based detection	• Coupling of assays for the detection of pathogenic DNA with SERS substrates.	• Detection of meningitis pathogenic DNA (LOD in pM range).^72 Detection of pathogen DNA in clinical CSF.^73
	• SERS nanotags functionalised with DNA/RNA aptamers.	• Detection of KSHV and BA DNA using LFA (LOD in fM range).^74
	• Supports label-based detection.	• Detection of S. aureus and S. typhimurium using aptamer-based magnetic sandwich assay (LOD 15 CFU mL^−1).^78
		• Detection of E. coli and S. aureus using aptamer-based magnetic sandwich assay in urine samples (LOD 50 CFU mL^−1, 1.5 hours, 20 CFU mL^−1 and 15 min for culture).^79
		• Detection of E. coli using aptamers in beef samples (LOD 100 CFU mL^−1, 20 min).^81
		• Detection of influenzae A H1N1 in complex mixtures (LOD 97 pfu mL^−1, 20 min).^82
		• Detection of DNA from 11 common RTI pathogens using LFA (LOD in fM range, 20 min). Detection from throat swab.^110
		• Detection of S. enterica and L. monocytogenes in milk, chicken and beef using LFA and RPA (LOD 22 CFU mL^−1).^111
		• Detection of plant pathogens on commercial crops using RPA outside of laboratory.^114
		• Real time detection of MRSA genes using miniaturized PCR system.^115
(4) Immunoassays	• Specific binding of pathogen antigen and antibodies coupled with SERS nanotags.	• Detection of Zika and dengue biomarkers using dipstick immunoassay (LOD 0.72 ng mL^−1).^86
	• Supports label-based detection.	• Detection of multiple viral strains using magnetic LFA (LOD 10 pfu mL^−1).^89 Detection in blood, serum and sputum (LOD 10^5 pfu mL^−1).
		• Detection of three bacterial pathogens using magnetic sandwich assay (LOD 10 CFU mL^−1).^90 Same LODs confirmed on portable system (1 hour).^108
		• Detection of multiple viral and bacterial pathogens in serum using magnetic sandwich assay (LOD 10 pg mL^−1).^91

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The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.

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