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The first selenium-containing pillar[5]arene-based macrocyclic amphiphile was synthesized. This amphiphile self-assembled in water to form vesicles with redox responsiveness. Furthermore, these pillar[5]arene-based vesicles were used in the controlled release of small molecules with DOX as the model compound.

Graphical abstract: A redox-responsive selenium-containing pillar[5]arene-based macrocyclic amphiphile: synthesis, controllable self-assembly in water, and application in controlled release

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