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The non-biofouling properties of a zwitterionic sulfobetaine polymer surface were easily made attractive to bioentities (e.g., proteins and cells) by metal–polyphenol coating, and spatio-selective functionalization of the zwitterionic polymer surface was achieved by using a soft lithographic technique.

Graphical abstract: One-step functionalization of zwitterionic poly[(3-(methacryloylamino)propyl)dimethyl(3-sulfopropyl)ammonium hydroxide] surfaces by metal–polyphenol coating

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