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The proof-of-concept for the modular synthesis of new functional soft gel materials based on amide–triazole isosteric replacement has been demonstrated. A coassembly approach of isosteric amino acid-based hydrogelators was fruitfully applied for fine-tuning the release of entrapped drugs.

Graphical abstract: Amide–triazole isosteric substitution for tuning self-assembly and incorporating new functions into soft supramolecular materials

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