Themed collection In memory of John S. Fossey – CAtalysis and SEnsing (CASE)
![](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/Ajax-GA-Loader.gif)
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Shape-shifting p-cyclophanes as portals to switching, sensing, delivery and logic operations in water
Switchable cyclophanes allow capture/release of guests to control their properties.
Org. Chem. Front., 2023,10, 1570-1576
https://doi.org/10.1039/D2QO02043B
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Sensitive dipstick assays for lectin detection, based on glycan–BSA conjugate immobilisation on gold nanoparticles
Gold nanoparticles and gold nanoshells functionalised with a selection of carbohydrates: glyco-nanoparticles towards lectin detection in a dipstick assay.
Org. Chem. Front., 2023,10, 3819-3829
https://doi.org/10.1039/D3QO00424D
A mannose-functionalized pillar[5]arene-based supramolecular fluorescent probe for real-time monitoring of gemcitabine delivery to cancer cells
A novel pillar[5]arene-based supramolecular fluorescent probe was constructed for the real-time monitoring of the nonfluorescent drug gemcitabine delivered to cancer cells.
Org. Chem. Front., 2023,10, 3491-3497
https://doi.org/10.1039/D3QO00476G
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Synthesis of atropisomeric phosphino-triazoles and their corresponding gold(I) complexes
The synthesis of atropisomeric phosphino-triazoles through a CuAAC approach is disclosed. Gold(I) chloride complexes of single-enantiomer phosphines were then prepared and again demonstrated to be conformationally stable.
Org. Chem. Front., 2023,10, 3460-3466
https://doi.org/10.1039/D3QO00322A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Ratiometric sensing of β-galactosidase based on excited-state intramolecular proton transfer (ESIPT) and solid-state luminescence enhancement
An ESIPT-based ratiometric probe with solid-state luminescence enhancement is developed for the sensitive detection of glycosidase activity.
Org. Chem. Front., 2023,10, 2913-2917
https://doi.org/10.1039/D3QO00605K
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Upper-rim functionalised calix[4]arenes for chemoselective Au3+ detection
We report the synthesis of a series of fluorophore and alkyne-derived 5,17-difunctionalised calix[4]arenes and their application in the detection of Au3+.
Org. Chem. Front., 2023,10, 2397-2404
https://doi.org/10.1039/D3QO00021D
A supramolecular near-infrared nanophotosensitizer from host-guest complex of lactose-capped pillar[5]arene with aza-BODIPY derivative for tumor eradication
A supramolecular NIR nanophotosensitizer for dual-modal imaging and ablation of tumors was constructed by loading disulfiram (DSF) into the vesicle from host–guest complex of lactose-capped pillar[5]arene (LacP5) with aza-BODIPY derivative (BSTA).
Org. Chem. Front., 2023,10, 1927-1935
https://doi.org/10.1039/D3QO00065F
Asymmetric synthesis of 7-membered-ring-bridged 3,4-fused tricyclic indoles via Friedel–Crafts alkylation/annulation
Regio- and enantioselective Friedel–Crafts alkylation/N-hemiacetalization and dehydration sequence were reported using Ni(II)-PyBPI complex as catalyst, affording chiral 7-membered-ring-bridged 3,4-fused tricyclic indoles in good results.
Org. Chem. Front., 2023,10, 1910-1914
https://doi.org/10.1039/D2QO01982E
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
A BODIPY-based probe for amyloid-β imaging in vivo
Probe BocBDP with a binding unit suitable for penetrating the BBB and imaging Aβ in vivo.
Org. Chem. Front., 2023,10, 1903-1909
https://doi.org/10.1039/D2QO02032G
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Synthesis of α-amino acid derived (1,2,3-triazol-4-yl)-picolinamide (tzpa) ligands and their corresponding luminescent Tb(III) complexes
The synthesis of chiral α-amino acid derived (1,2,3-triazol-4-yl)-picolinamide (tzpa) ligands 4–6 designed by combining the coordination properties of two well-known ligand structures within a single unit is described.
Org. Chem. Front., 2023,10, 1915-1926
https://doi.org/10.1039/D3QO00232B
Determination of enantiomeric excess and diastereomeric excess via optical methods. Application to α-methyl-β-hydroxy-carboxylic acids
Characterization of chiral molecules in solution is paramount for measuring reaction success.
Org. Chem. Front., 2023,10, 1386-1392
https://doi.org/10.1039/D2QO01444K
Chemical fuel-driven gelation with dissipative assembly-induced emission
A dissipative self-assembly system based on G1 and G2 was fabricated by using dimethyl sulfate as chemical fuel. The mixed solution rapidly transformed into a hybrid hydrogel upon adding the fuel, accompanied by a significant emission enhancement.
Org. Chem. Front., 2023,10, 1380-1385
https://doi.org/10.1039/D2QO01888H
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Fluorometric detection of volatile amines using an indanonalkene platform
An “indanonalkene” fluorescent chemosensor captured volatile amines via an amine–thiol scrambling reaction, and was applied to prepare portable paper-based sensors and polymeric film sensors for point-of-care detection of amines.
Org. Chem. Front., 2023,10, 1393-1398
https://doi.org/10.1039/D2QO02023H
An extended quinoid molecule based on bis(thiophene-diketopyrrolopyrrole) with balanced ambipolar semiconducting properties and strong near-infrared absorption
A NIR strong absorbing molecule was constructed by taking the structural advantages of a quinoid and diketopyrrolopyrrole, with an absorption maximum of up to 1039 nm and hole and electron mobilities up to 0.19 and 0.2 cm2 V−1 s−1, respectively.
Org. Chem. Front., 2023,10, 632-639
https://doi.org/10.1039/D2QO01678H
Tetraamidoindolyl calix[4]arene as a selective ion pair receptor for LiCl
A calix[4]arene (1) functionalized with amidoindole groups on the upper rim and with propyl groups on the lower rim extracts LiCl and LiBr selectively.
Org. Chem. Front., 2022,9, 6888-6893
https://doi.org/10.1039/D2QO01519F
Hypochlorous acid-activated two-photon fluorescent probe for evaluation of anticancer drug-induced cardiotoxicity and screening of antioxidant drugs
THPIC was developed to detect HClO in lysosomes. The results showed that HClO could be used as a biomarker for evaluating drug-induced cardiotoxicity, and THPIC could be applied as a platform for screening drugs to prevent cardiotoxicitys.
Org. Chem. Front., 2022,9, 6795-6801
https://doi.org/10.1039/D2QO01408D
Visible-light enabled synthesis of cyclopropane-fused indolines via dearomatization of indoles
An efficient synthesis of methylene-unsubstituted cyclopropane-fused indolines via photoredox catalyzed dearomative cyclopropanation of indole derivatives was developed.
Org. Chem. Front., 2022,9, 5463-5468
https://doi.org/10.1039/D2QO01174C
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Impact of varying the phenylboronic acid position in macrocyclic Eu(III) complexes on the recognition of adenosine monophosphate
We present a series of sterically demanding Eu(III) complexes and identify the optimal position of the peripheral phenylboronic acid to achieve the multisite recognition of AMP (adenosine monophosphate) in aqueous solution.
Org. Chem. Front., 2022,9, 5494-5504
https://doi.org/10.1039/D2QO01067D
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
4,7-Diarylbenzo[c][1,2,5]thiadiazoles as fluorophores and visible light organophotocatalysts
A library of 26 electron donor-acceptor organophotocatalysts based on the benzo[c][1,2,5]thiadiazole (BTZ) group has been developed. These visible light organophotocatalysts were then used in a Minisci-type alkylation of heteroarenes under both batch and continuous flow conditions.
Org. Chem. Front., 2022,9, 5473-5484
https://doi.org/10.1039/D2QO01316A
About this collection
This themed collection, featured in Organic Chemistry Frontiers, is dedicated to the late Professor John S. Fossey, who passed away on Friday, April 15th, 2022.
Professor John S. Fossey had been heavily involved with Organic Chemistry Frontiers since its launch ten years ago. As a member of the Advisory Board, he witnessed the journal's growth and supported its numerous achievements. Professor Fossey's significant contribution to Organic Chemistry Frontiers, a collaboration between the UK and China, marked the culmination of his lifelong commitment to promoting catalysis and sensing research through international collaborations.
Guest Editors Tony D. James (Bath University), Steven D. Bull (Bath University), Shu-Li You (SIOC), and Xuhong Qian (ECUST & ECNU) extend their heartfelt appreciation for contributions made by Professor Fossey’s friends and colleagues to this collection.