Themed collection Iron and zinc sensing in cells and the body
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Iron and zinc sensing in cells and the body
This editorial introduces a collection of papers presented at a symposium at King’s College London in December 2013. The Iron Metabolism Research Group organized this meeting that focused on “zinc and iron sensing in cells and tissues.
Metallomics, 2015,7, 200-201
https://doi.org/10.1039/C4MT90051K
Iron regulatory proteins and their role in controlling iron metabolism
Cellular and body iron homeostasis are regulated by iron-sensing and post-transcriptional feedback mechanisms, which control iron uptake, release, storage and heme biosythesis.
Metallomics, 2015,7, 232-243
https://doi.org/10.1039/C4MT00164H
Relationship between the architecture of zinc coordination and zinc binding affinity in proteins – insights into zinc regulation
Relationship between the architecture and stability of zinc proteins.
Metallomics, 2015,7, 244-257
https://doi.org/10.1039/C4MT00094C
Analyzing free zinc(II) ion concentrations in cell biology with fluorescent chelating molecules
Chelation-induced fluorescence changes in low molecular weight molecules (probes) and genetically encoded proteins (sensors) allow for measuring fluctuations of cellular zinc(II) ion concentrations.
Metallomics, 2015,7, 202-211
https://doi.org/10.1039/C4MT00230J
Iron and oxygen sensing: a tale of 2 interacting elements?
Iron and oxygen metabolism are intimately linked with one another.
Metallomics, 2015,7, 223-231
https://doi.org/10.1039/C4MT00225C
Iron-sensitive fluorescent probes: monitoring intracellular iron pools
Several iron-sensitive fluorophores have been investigated in a range of cell types in order to quantify iron(II) levels in the cytosol and the cytoplasm.
Metallomics, 2015,7, 212-222
https://doi.org/10.1039/C4MT00214H
Genetically-encoded FRET-based sensors for monitoring Zn2+ in living cells
We discuss the development and application of genetically-encoded FRET sensors as attractive tools to study intracellular Zn2+ homeostasis and signaling.
Metallomics, 2015,7, 258-266
https://doi.org/10.1039/C4MT00179F
About this collection
This collection of articles features work presented at a one day symposium at King’s College London in December 2013, the 45 th such meeting organised by the Iron Metabolism Group based as the college. The article collection is dedicated to iron and zinc sensing in cells and the body and is introduced in the Editorial by Professor Robert C. Hider and Professor Wolfgang Maret.