Themed collection SPEC 2018: International Society of Clinical Spectroscopy
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SPEC 2018: International Society of Clinical Spectroscopy
Welcome to the latest themed issue on the topic of Optical Diagnosis in Analyst, guest-edited by Dr. Matthew Baker.
Analyst, 2018,143, 5872-5873
https://doi.org/10.1039/C8AN90098A
Prospective on using fibre mid-infrared supercontinuum laser sources for in vivo spectral discrimination of disease
Mid-infrared (MIR) fibre-optics may play a future role in in vivo diagnosis of disease, including cancer.
Analyst, 2018,143, 5874-5887
https://doi.org/10.1039/C8AN01396A
Biomedical applications of mid-infrared quantum cascade lasers – a review
Quantum cascade lasers with high spectral power density and narrow band emission profiles provide novel access to biomedical applications.
Analyst, 2018,143, 5888-5911
https://doi.org/10.1039/C8AN01306C
Clinical applications of infrared and Raman spectroscopy: state of play and future challenges
This review examines the state-of-the-art of clinical applications of infrared absorption and Raman spectroscopy, outstanding challenges, and progress towards translation.
Analyst, 2018,143, 1735-1757
https://doi.org/10.1039/C7AN01871A
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Dual purpose fibre – SERS pH sensing and bacterial analysis
A way to incorporate SERS nanosensors on the end of an optical fibre that also allows for the extraction of bacterial samples.
Analyst, 2018,143, 5918-5925
https://doi.org/10.1039/C8AN01322E
Application of a quantum cascade laser aperture scanning near-field optical microscope to the study of a cancer cell
First IR-SNOM images over the Amide I band taken in the centre of an oesophageal cancer cell.
Analyst, 2018,143, 5912-5917
https://doi.org/10.1039/C8AN01183D
Three-dimensional depth profiling of prostate tissue by micro ATR-FTIR spectroscopic imaging with variable angles of incidence
Variable angle micro ATR-FTIR, via the insertion of circular apertures, was used to measure tissue samples at various penetration depths.
Analyst, 2019,144, 2954-2964
https://doi.org/10.1039/C8AN01929K
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Tandem fluorescence and Raman (fluoRaman) characterisation of a novel photosensitiser in colorectal cancer cell line SW480
A novel photosensitiser, DC473, designed with solvatochromatic fluorescence and distinct Raman signal, is detected with tandem fluoRaman in SW480 cells.
Analyst, 2018,143, 6113-6120
https://doi.org/10.1039/C8AN01461B
![Open Access](https://www.rsc-cdn.org/pubs-core/2022.0.147/content/NewImages/open-access-icon-orange.png)
Characterization of inflammatory breast cancer: a vibrational microspectroscopy and imaging approach at the cellular and tissue level
Inflammatory breast cancer (IBC) has a poor prognosis because of the lack of specific biomarkers and its late diagnosis.
Analyst, 2018,143, 6103-6112
https://doi.org/10.1039/C8AN01292J
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Hyperspectral analysis applied to micro-Brillouin maps of amyloid-beta plaques in Alzheimer's disease brains
Non-negative factorization analysis applied to spontaneous Brillouin microscopy maps of amyloid-beta plaques in a transgenic mouse model enables to resolve spatially distinct components with specific mechanical properties.
Analyst, 2018,143, 6095-6102
https://doi.org/10.1039/C8AN01291A
Optimised spectral pre-processing for discrimination of biofluids via ATR-FTIR spectroscopy
Pre-processing is an essential step in the analysis of spectral data.
Analyst, 2018,143, 6121-6134
https://doi.org/10.1039/C8AN01384E
Exploring the efficacy and cellular uptake of sorafenib in colon cancer cells by Raman micro-spectroscopy
This study demonstrates the efficacy and distribution of sorafenib in colon cancer cells by label-free Raman microscopy.
Analyst, 2018,143, 6069-6078
https://doi.org/10.1039/C8AN02029A
Different binding sites of serum albumins in the protein corona of gold nanoparticles
Binding sites of albumins on gold nanoparticles were characterized by surface-enhanced Raman scattering.
Analyst, 2018,143, 6061-6068
https://doi.org/10.1039/C8AN01321G
Raman spectroscopic features of primary cardiac microvascular endothelial cells (CMECs) isolated from the murine heart
Gaining knowledge on the biochemical profile of primary endothelial cells on a subcellular level can contribute to better understanding of cardiovascular disease.
Analyst, 2018,143, 6079-6086
https://doi.org/10.1039/C8AN01308J
ATR-FTIR spectroscopy shows changes in ovarian cancer cells after incubation with novel organoamidoplatinum(II) complexes
ATR-FTIR spectroscopy has been applied to compare the effect of new organoamidoplatinum(II) complexes with cisplatin on cells from a cisplatin-sensitive and a cisplatin-resistant ovarian cancer cell line.
Analyst, 2018,143, 6087-6094
https://doi.org/10.1039/C8AN01558A
A high-throughput serum Raman spectroscopy platform and methodology for colorectal cancer diagnostics
Translating Raman spectroscopy for colorectal cancer diagnosis with a focus on high-throughput design, inter-user variability and sample handling considerations.
Analyst, 2018,143, 6014-6024
https://doi.org/10.1039/C8AN01323C
Dual excitation wavelength system for combined fingerprint and high wavenumber Raman spectroscopy
A probe-based Raman spectroscopy system using a single laser module with two excitation wavelengths has been developed for measuring the fingerprint and high wavenumber regions with a single detector.
Analyst, 2018,143, 6049-6060
https://doi.org/10.1039/C8AN01989D
New insights of Raman spectroscopy for oral clinical applications
Oral injuries are currently diagnosed by histopathological analysis of biopsy, which is an invasive procedure and does not give immediate results.
Analyst, 2018,143, 6037-6048
https://doi.org/10.1039/C8AN01363B
Raman spectroscopy of stored red blood cell concentrate within sealed transfusion blood bags
Spectral information relevant to the quality of stored blood can be obtained in situ through sealed blood transfusion bags using a commercially available instrument.
Analyst, 2018,143, 6006-6013
https://doi.org/10.1039/C8AN01509K
Towards a quantum cascade laser-based implant for the continuous monitoring of glucose
An in vitro investigation of a quantum cascade laser-based transflection optofluidic interface for the continuous glucose monitoring in biofluids is presented with respect to its glucose sensitivity and specificity, its glucose exchange time, its resistance against temperature variations and its long-term stability.
Analyst, 2018,143, 6025-6036
https://doi.org/10.1039/C8AN01382A
Optimizing decision tree structures for spectral histopathology (SHP)
This paper reviews methods to arrive at optimum decision tree or label tree structures to analyze large SHP datasets.
Analyst, 2018,143, 5935-5939
https://doi.org/10.1039/C8AN01303A
Near-field infrared nanospectroscopy and super-resolution fluorescence microscopy enable complementary nanoscale analyses of lymphocyte nuclei
First near-field infrared spectroscopy and imaging of lymphocyte nucleus at 30 nm spatial resolution reveals spectrochemically distinct regions in nuclear organization.
Analyst, 2018,143, 5926-5934
https://doi.org/10.1039/C8AN01341A
Raman spectroscopic analysis of high molecular weight proteins in solution – considerations for sample analysis and data pre-processing
This study explores the potential of Raman spectroscopy, coupled with multivariate regression techniques and ion exchange chromatography, to quantitatively monitor diagnostically relevant changes in high molecular weight proteins in liquid plasma.
Analyst, 2018,143, 5987-5998
https://doi.org/10.1039/C8AN01701H
Raman spectroscopy as a novel tool for fast characterization of the chemical composition of perivascular adipose tissue
One of the new targets of untapped therapeutic potential is perivascular adipose tissue (pVAT). Based on Raman spectroscopy we demonstrated that the lipid unsaturation degree was clearly distinct in various types of adipose tissues, in particular thoracic and abdominal pVATs, and was influenced by the age of animals.
Analyst, 2018,143, 5999-6005
https://doi.org/10.1039/C8AN01307A
How to unravel the chemical structure and component localization of individual drug-loaded polymeric nanoparticles by using tapping AFM-IR
We describe here the theoretical basis of the innovative tapping AFM-IR mode that can address novel challenges in imaging and chemical mapping of polymeric nanoparticles.
Analyst, 2018,143, 5940-5949
https://doi.org/10.1039/C8AN01239C
Diagnosis of pancreatic cancer via1H NMR metabolomics of human plasma
The investigation of blood plasma via1H NMR metabolomics revealed a panel of potential biomarkers of pancreatic cancer.
Analyst, 2018,143, 5974-5978
https://doi.org/10.1039/C8AN01310A
Vibrational spectroscopic monitoring and biochemical analysis of pericellular matrix formation and maturation in a 3-dimensional chondrocyte culture model
PCA score of FTIR spectra in fingerprint region for cultured chondrocytes at day 7, 14 and 21 in HA hydrogel showing that the 3D culture drove chondrocytes (CY) to chondron-like (CN) structure dynamically.
Analyst, 2018,143, 5979-5986
https://doi.org/10.1039/C8AN01272E
Surface enhanced resonance Raman spectroscopy (SERRS) for probing through plastic and tissue barriers using a handheld spectrometer
Through tissue imaging of a live breast cancer tumour model using handheld surface enhanced resonance Raman spectroscopy (SERRS).
Analyst, 2018,143, 5965-5973
https://doi.org/10.1039/C8AN01249K
Blood-based near-infrared spectroscopy for the rapid low-cost detection of Alzheimer's disease
Plasma samples deposited on low-E slides were analysed in transmission mode by using a FT-NIR spectrometer in order to detect Alzheimer's disease using computer-based methods.
Analyst, 2018,143, 5959-5964
https://doi.org/10.1039/C8AN01205A
Non-invasive analysis of stored red blood cells using diffuse resonance Raman spectroscopy
A method to acquire the Raman spectra of sub-surface components using diffusely focused radiation in a microscope sampling configuration is described.
Analyst, 2018,143, 5950-5958
https://doi.org/10.1039/C8AN01135D
About this collection
This collection of articles highlights work from the 10th conference in the successful SPEC series, held in Glasgow, UK, 10 June – 15 June 2018. The meeting featured research from scientists and clinicians, both from academia and industry, who are developing spectroscopic instrumentation and techniques to improve world health. Guest Edited by Conference Organising Committee Chair and Analyst Advisory Board Member Matthew Baker (University of Strathclyde, UK), the collection includes a topical review article by Hugh J. Byrne et al. titled “ Clinical applications of infrared and Raman spectroscopy: state of play and future challenges”.