This review highlights the strategy of photocatalytic fluoroalkyl radical-induced cyclization for synthesizing 5–7 membered fluorinated heterocycles.
The fluorinated heterocycles are main components of 20% of the anticancer and antibiotic drugs, this review describes the reported anticancer and antimicrobial activities of the fluorinated five-membered heterocycles and their benzo-fused systems.
A Rh-catalyzed two-fold C–F bond cleavage enabled [4 + 2] annulation reaction via CF3-carbenoid C–H functionalization of arenes with indoles or various classes of azoles as the directing groups was developed.
This review highlights the key advances in the synthesis and applications of 2-aza-bicyclohexanes and 2-oxabicyclohexanes for medicinal chemistry.
Radical additions to nitroalkenes occur in a regiocomplementary fashion compared to nucleophilic conjugate additions, leading to alkenes upon denitration. Carbon-centered radicals as well as heteroatom-based radicals can be used for this process.