Issue 13, 2019

High thermal stability, pH responsive organogels of 2H-benzo[d]1,2,3-triazole derivatives as pharmaceutical crystallization media

Abstract

2H-Benzo[d]1,2,3-triazole derivatives with a range of chemical functionalities showed significant organogel formation, particularly bis-amide derivative 4e which gave robust thermally stable gels, in a range of solvents down to 0.1 wt%. The gelators proved responsive under pH stimuli or to the presence of metal cations. The gels also proved to be useful vehicles to crystallize pharmaceutical drugs, resulting in a change in polymorphic outcome in the case of sulfathiazole compared to the solution crystallization outcome.

Graphical abstract: High thermal stability, pH responsive organogels of 2H-benzo[d]1,2,3-triazole derivatives as pharmaceutical crystallization media

Supplementary files

Article information

Article type
Paper
Submitted
12 Қаз. 2018
Accepted
27 Қар. 2018
First published
27 Қар. 2018

CrystEngComm, 2019,21, 2135-2143

High thermal stability, pH responsive organogels of 2H-benzo[d]1,2,3-triazole derivatives as pharmaceutical crystallization media

I. Torres-Moya, B. Saikia, P. Prieto, J. R. Carrillo and J. W. Steed, CrystEngComm, 2019, 21, 2135 DOI: 10.1039/C8CE01742E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements