Issue 45, 2018

Catalytic carbene/alkyne metathesis (CAM): a versatile strategy for alkyne bifunctionalization

Abstract

Metal carbene, as a reactive intermediate, has shown versatile applications in modern organic synthesis. One of the priorities in this area is exploration of stable carbene precursors with structural diversity. Catalytic carbene/alkyne metathesis (CAM) with readily available and stable materials, such as α-carbonyl diazo compounds, provides an effective approach for the in situ generation of vinyl carbene intermediates, which is difficult to directly access with other carbene precursors. Thus, novel cascade transformations involving the CAM process for the straightforward construction of polycyclic frameworks have been well documented. Challenges including side reaction control and asymmetric catalysis in this area need to be explored. This review will summarize the recent advances in this field and be divided by the type of the terminating carbene reactions.

Graphical abstract: Catalytic carbene/alkyne metathesis (CAM): a versatile strategy for alkyne bifunctionalization

Article information

Article type
Review Article
Submitted
28 Қыр. 2018
Accepted
25 Қаз. 2018
First published
26 Қаз. 2018

Org. Biomol. Chem., 2018,16, 8677-8685

Catalytic carbene/alkyne metathesis (CAM): a versatile strategy for alkyne bifunctionalization

C. Pei, C. Zhang, Y. Qian and X. Xu, Org. Biomol. Chem., 2018, 16, 8677 DOI: 10.1039/C8OB02420K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements