Issue 50, 2018

Design of functionalized cyclic peptides through orthogonal click reactions for cell culture and targeting applications

Abstract

An approach for the design of functionalized cyclic peptides is established for use in 3D cell culture and in cell targeting. Sequential orthogonal click reactions, specifically a photoinitiated thiol–ene and strain promoted azide–alkyne cycloaddition, were utilized for peptide cyclization and conjugation relevant for biomaterial and biomedical applications, respectively.

Graphical abstract: Design of functionalized cyclic peptides through orthogonal click reactions for cell culture and targeting applications

Supplementary files

Article information

Article type
Communication
Submitted
27 Сәу. 2018
Accepted
24 Мам. 2018
First published
29 Мам. 2018

Chem. Commun., 2018,54, 6923-6926

Design of functionalized cyclic peptides through orthogonal click reactions for cell culture and targeting applications

P. J. LeValley, E. M. Ovadia, C. A. Bresette, L. A. Sawicki, E. Maverakis, S. Bai and A. M. Kloxin, Chem. Commun., 2018, 54, 6923 DOI: 10.1039/C8CC03218A

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