Issue 3, 2017

(Q)SARs to predict environmental toxicities: current status and future needs

Abstract

The current state of the art of (Quantitative) Structure–Activity Relationships ((Q)SARs) to predict environmental toxicity is assessed along with recommendations to develop these models further. The acute toxicity of compounds acting by the non-polar narcotic mechanism of action can be well predicted, however other approaches, including read-across, may be required for compounds acting by specific mechanisms of action. The chronic toxicity of compounds to environmental species is more difficult to predict from (Q)SARs, with robust data sets and more mechanistic information required. In addition, the toxicity of mixtures is little addressed by (Q)SAR approaches. Developments in environmental toxicology including Adverse Outcome Pathways (AOPs) and omics responses should be utilised to develop better, more mechanistically relevant, (Q)SAR models.

Graphical abstract: (Q)SARs to predict environmental toxicities: current status and future needs

Article information

Article type
Perspective
Submitted
19 Жел. 2016
Accepted
16 Ақп. 2017
First published
17 Ақп. 2017

Environ. Sci.: Processes Impacts, 2017,19, 213-220

(Q)SARs to predict environmental toxicities: current status and future needs

M. T. D. Cronin, Environ. Sci.: Processes Impacts, 2017, 19, 213 DOI: 10.1039/C6EM00687F

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