Issue 9, 2016

Pd(ii)-catalyzed direct functionalization of C–H bonds of benzamides for synthesis of 1,1-difluoro-1-alkenes

Abstract

Pd-catalyzed direct difluoroallylation of C–H bonds of benzamides with readily available Rf-Br reagents is reported. The reaction proceeds via Pd-catalyzed C–H activation, followed by reaction of the resulting intermediate with 3-bromo-3,3-difluoropropene (BDFP) in a γ-selective fashion. The C–H functionalization process was characterized by a broad substrate scope as well as an excellent functional-group tolerance.

Graphical abstract: Pd(ii)-catalyzed direct functionalization of C–H bonds of benzamides for synthesis of 1,1-difluoro-1-alkenes

Supplementary files

Article information

Article type
Research Article
Submitted
28 Сәу. 2016
Accepted
17 Мау. 2016
First published
20 Мау. 2016

Org. Chem. Front., 2016,3, 1080-1083

Pd(II)-catalyzed direct functionalization of C–H bonds of benzamides for synthesis of 1,1-difluoro-1-alkenes

C. Li, D. Zhang, W. Zhu, P. Wan and H. Liu, Org. Chem. Front., 2016, 3, 1080 DOI: 10.1039/C6QO00178E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements