Recent advances in three-component radical acylative difunctionalization of unsaturated carbon–carbon bonds

Abstract

The radical acylated difunctionalization of unsaturated carbon–carbon bonds, which introduces acyl and other groups simultaneously, represents an attractive approach for the synthesis of functionalized ketones or related derivatives from easily accessible feedstocks. A wide range of acylation reagents, including carbazates, α-keto acid, acyl-1,4-dihydropyridines, aldehydes, oxime esters, oxime oxalate, and carboxylic acid derivatives, etc., can be used to incorporate acyl groups into olefins, dienes, alkynes, 1,3-enynes, cyclopropanes, and allenes. This review highlights the recent advances in this topic and focuses on the mechanistic insights of these transformations.