Issue 22, 2023

Recent progress on radiofluorination using metals: strategies for generation of C–18F bonds

Abstract

C–F bond formation is an important research topic in organic synthesis because of the wide use of organofluorine compounds in various areas including pharmaceuticals, agricultural applications, and materials science. In particular, C–18F bond formation by incorporation of fluorine-18 (18F) with organic molecules is an important process to produce 18F-labeled radiotracers, which are commonly used in Positron Emission Tomography (PET). Several novel fluorination techniques have been developed due to the growing clinical demand for 18F radiotracers. Metal-mediated radiofluorination is a reliable method for the formation of C–18F bonds to produce 18F-labeled molecules compared to other methods. In this review, we summarize recent advances in the generation of C–18F bonds through metal-catalyzed radiofluorination.

Graphical abstract: Recent progress on radiofluorination using metals: strategies for generation of C–18F bonds

Article information

Article type
Review Article
Submitted
23 Мам. 2023
Accepted
26 Қыр. 2023
First published
27 Қыр. 2023

Org. Chem. Front., 2023,10, 5746-5781

Recent progress on radiofluorination using metals: strategies for generation of C–18F bonds

T. G. Luu and H. Kim, Org. Chem. Front., 2023, 10, 5746 DOI: 10.1039/D3QO00772C

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