Issue 35, 2023

Conservation of the enzyme-like activity and biocompatibility of CeO2 nanozymes in simulated body fluids

Abstract

Cerium oxide nanozymes (CeO2NZs) are attracting vast attention due to their antioxidant and catalytic properties and mimic the activities of multiple endogenous enzymes. However, as is the case for nanomedicines in general, the success in showing their unique medical applications has not been matched by an understanding of their pharmacokinetics, which is delaying their implementation in clinical settings. Furthermore, the data of their modifications in body fluids and the impact on their activity are scarce. Herein, two types of widely used CeO2NZs, electrostatically stabilized and coated with a mesoporous silica shell, were exposed to simulated saliva and lung, gastric and intestinal fluids, and cell culture media. Their physicochemical modifications and bioactivity were tracked over time up to 15 days combining the data of different characterization techniques and biological assays. The results show that the biocompatibility and antioxidant activity are retained in all cases despite the different evolution behaviors in different fluids, including agglomeration. This work provides an experimental basis from a pharmacokinetic perspective that supports the therapeutic effectiveness of CeO2NZs observed in vivo for the treatment of many conditions related to chronic inflammation and cancer, and suggests that they can be safely administered through different portals of entry including intravenous injection, oral ingestion or inhalation.

Graphical abstract: Conservation of the enzyme-like activity and biocompatibility of CeO2 nanozymes in simulated body fluids

  • This article is part of the themed collection: Nanozymes

Supplementary files

Article information

Article type
Paper
Submitted
19 Шіл. 2023
Accepted
08 Там. 2023
First published
10 Там. 2023

Nanoscale, 2023,15, 14365-14379

Conservation of the enzyme-like activity and biocompatibility of CeO2 nanozymes in simulated body fluids

M. Zeng, X. Zhang, J. Tang, X. Liu, Y. Lin, D. Guo, Y. Zhang, S. Ju, G. Fernández-Varo, Y. Wang, X. Zhou, G. Casals and E. Casals, Nanoscale, 2023, 15, 14365 DOI: 10.1039/D3NR03524G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements