Issue 47, 2023

Targeted delivery of alcohol-containing payloads with antibody-drug conjugates

Abstract

We herein describe the cell-specific release of alcohol-containing payloads via a sulfatase-sensitive linker in antibody-drug conjugates (ADCs). The linker shows efficient sulfatase-mediated release and high stability in human and mouse plasma. In vitro evaluation demonstrates potent antigen dependent toxicity towards breast cancer cell lines.

Graphical abstract: Targeted delivery of alcohol-containing payloads with antibody-drug conjugates

Supplementary files

Article information

Article type
Communication
Submitted
31 Нау. 2023
Accepted
16 Мам. 2023
First published
17 Мам. 2023

Chem. Commun., 2023,59, 7240-7242

Targeted delivery of alcohol-containing payloads with antibody-drug conjugates

K. E. Grier, A. H. Hansen, C. S. Haxvig, X. Li, O. Krigslund, N. Behrendt, L. H. Engelholm, F. Rossi, B. C. Sousa, G. J. Harradence, N. Camper and K. M. Qvortrup, Chem. Commun., 2023, 59, 7240 DOI: 10.1039/D3CC01596C

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