Issue 19, 2023

An electrochemical approach for the prediction of Δ9-tetrahydrocannabinolic acid and total cannabinoid content in Cannabis sativa L.

Abstract

Two electrochemical sensors are proposed here for the first time for the fast screening of cannabinoids in Cannabis sativa L. plant material (inflorescences). The accurate control of cannabinoid content is important for discriminating between recreational, i.e. illegal, and fibre-type C. sativa samples, which differ mainly according to the amount of Δ9-tetrahydrocannabinol (Δ9-THC) and Δ9-tetrahydrocannabinolic acid (Δ9-THCA). Two screen printed electrodes obtained using different electrode materials were tested for the analysis of extracts from recreational and fibre-type C. sativa and their performance was compared with a consolidated method based on high-performance liquid chromatography (HPLC). The voltammetric responses recorded in the different samples reflected the compositional differences of the recreational and fibre-type extracts in accordance with the results of HPLC analyses. Moreover, the quantification of Δ9-THCA and the total cannabinoid content on the basis of the intensity of the peaks of the voltammograms was possible through a simple and fast electrochemical procedure.

Graphical abstract: An electrochemical approach for the prediction of Δ9-tetrahydrocannabinolic acid and total cannabinoid content in Cannabis sativa L.

Supplementary files

Article information

Article type
Paper
Submitted
29 Мау. 2023
Accepted
24 Шіл. 2023
First published
25 Шіл. 2023

Analyst, 2023,148, 4688-4697

An electrochemical approach for the prediction of Δ9-tetrahydrocannabinolic acid and total cannabinoid content in Cannabis sativa L.

A. Monari, S. Cantalù, B. Zanfrognini, V. Brighenti, P. Verri, C. Zanardi, F. Pellati and L. Pigani, Analyst, 2023, 148, 4688 DOI: 10.1039/D3AN01090B

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