Issue 84, 2022

A cascade reaction of indolyl-migratory isocyanide insertion, scaffold rearrangement and redox-neutral event with isocyanide as a C(sp3)H–N synthon efficiently constructs indolylisoindolinones

Abstract

Herein, we report a Pd(0)-catalyzed cascade reaction of intramolecular indolyl isocyanide-insertion, isocyanide-initiated scaffold-rearrangement with indolyl migration and redox-neutral process, which affords an efficient access to indolylisoindolinones. Isocyanide as a C(sp3)H–N synthon and the alkyl motif of isocyanide as a hydride source have been explored for the first time.

Graphical abstract: A cascade reaction of indolyl-migratory isocyanide insertion, scaffold rearrangement and redox-neutral event with isocyanide as a C(sp3)H–N synthon efficiently constructs indolylisoindolinones

Supplementary files

Article information

Article type
Communication
Submitted
31 Шіл. 2022
Accepted
22 Қыр. 2022
First published
23 Қыр. 2022

Chem. Commun., 2022,58, 11827-11830

A cascade reaction of indolyl-migratory isocyanide insertion, scaffold rearrangement and redox-neutral event with isocyanide as a C(sp3)H–N synthon efficiently constructs indolylisoindolinones

S. Sisodiya, A. Acharya, M. Nagpure, N. Roy, S. K. Giri, H. R. Yadav, A. R. Choudhury and S. K. Guchhait, Chem. Commun., 2022, 58, 11827 DOI: 10.1039/D2CC04273H

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