Issue 27, 2021

Methionine-based carbon monoxide releasing polymer for the prevention of biofilm formation

Abstract

Carbon monoxide (CO) is being increasingly appreciated as a major physiological gasomediator and plays significant roles in different biological activities. However, site-specific delivery of this toxic gas faces major difficulties in the healthcare system in terms of unavailability of appropriate equipment for delivery. A well-known and most studied carbon monoxide releasing molecule (CORM) is tricarbonyldichlororuthenium(II) dimer (Ru2Cl4(CO)6). However, its use as a therapeutic agent is restricted due to its poor water solubility and a short half-life. In order to solve this issues we have designed and synthesized a water-soluble methionine (methionine methacryloyloxyethyl ester (METMA)) and poly(ethylene glycol methyl ether methacrylate) containing block-copolymer via reversible addition–fragmentation chain transfer (RAFT) polymerization and attached the CORM in the methionine side chain units. Inductively coupled plasma optical emission spectrometry (ICP-OES) and FT-IR confirms the presence of CORM molecule into the polymer. The time-dependent CO release from CORM conjugated block-copolymer was investigated by a myoglobin assay. This CORM conjugated block-copolymer slowly and spontaneously released CO with sustained-release kinetics. Moreover, this CO-releasing polymer was able to prevent biofilm formation against Pseudomonas aeruginosa.

Graphical abstract: Methionine-based carbon monoxide releasing polymer for the prevention of biofilm formation

Supplementary files

Article information

Article type
Paper
Submitted
22 Сәу. 2021
Accepted
21 Мау. 2021
First published
23 Мау. 2021

Polym. Chem., 2021,12, 3968-3975

Methionine-based carbon monoxide releasing polymer for the prevention of biofilm formation

B. Maiti, G. Ng, A. Abramov, C. Boyer and D. D. Díaz, Polym. Chem., 2021, 12, 3968 DOI: 10.1039/D1PY00546D

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements