Perforalactones D and E, two new C-20 quassinoids with potential activity to induce lysosomal biogenesis from the twigs of Harrisonia perforata (Blanco) Merr.

Shuai Liu; Cui-Shan Zhang; Xiao-Qian Ran; Xiao-Han Tang; Ya-Rong Guo; Ying Yan; Yong-Gang Yao; Xiao-Jiang Hao; Rong-Can Luo; Ying-Tong Di

doi:10.1039/D1OB01927A

Perforalactones D and E, two new C-20 quassinoids with potential activity to induce lysosomal biogenesis from the twigs of Harrisonia perforata (Blanco) Merr.†

Shuai Liu,‡^ab Cui-Shan Zhang,‡^ab Xiao-Qian Ran,

‡^cb Xiao-Han Tang,^a Ya-Rong Guo,

^d Ying Yan,^e Yong-Gang Yao,^cbf Xiao-Jiang Hao,

^a Rong-Can Luo

*^bc and Ying-Tong Di

*^ab

Author affiliations

* Corresponding authors

^a State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China
E-mail: diyt@mail.kib.ac.cn

^b Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan 650204, China

^c Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650204, China
E-mail: luorongcan@mail.kiz.ac.cn

^d School of Life Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230026, China

^e Guizhou Chemical Drug Research and Development Engineering Technical Center, Guizhou Medicinal University, Guiyang 550004, China

^f CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, China

Abstract

Two new quassinoids (1 and 2) were isolated from the twigs of Harrisonia perforata (Blanco) Merr. Perforalactone E (2) possesses an uncommon hexacyclic 1α,12α:5α,13α-dicyclo-9βH-picrasane skeleton. Its structure was determined based on spectroscopic data and X-ray crystallography. Compounds 1 and 2 could significantly induce lysosomal biogenesis through transcriptional activation of lysosomal genes.

This article is part of the themed collection: Chemical Biology in OBC

Organic & Biomolecular Chemistry

Perforalactones D and E, two new C-20 quassinoids with potential activity to induce lysosomal biogenesis from the twigs of Harrisonia perforata (Blanco) Merr.†

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Perforalactones D and E, two new C-20 quassinoids with potential activity to induce lysosomal biogenesis from the twigs of Harrisonia perforata (Blanco) Merr.

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