A photoelectrochemical biosensor based on methylene blue sensitized Bi5O7I for sensitive detection of PSA

Abstract

Herein, bismuth oxyiodide (Bi₅O₇I) was used as a signal probe to construct an effective sensitization structure with methylene blue (MB), combined with protein conversion strategy, and a photoelectrochemical (PEC) biosensor was constructed for sensitive detection of prostate-specific antigen (PSA). The designed biosensor had a high sensitivity and a low detection limit (LOD) of 0.047 fg mL⁻¹, which opened up a simple way for the detection of PSA and showed a good application prospect in clinical and medical fields.