Electrochemical trifluoromethylation/cyclization for the synthesis of isoquinoline-1,3-diones and oxindoles

Abstract

Herein, we describe a protocol for electrochemical cathode reduction to generate trifluoromethyl radicals. The trifluoromethylation reagent (IMDN-SO₂CF₃) used in this strategy is inexpensive and easy to obtain, and the reaction can be conducted efficiently without the addition of additional redox reagents. Using this strategy, we achieved electrochemical trifluoromethylation/cyclization for the synthesis of isoquinoline-1,3-diones and oxindoles. This protocol has good functional group tolerance and a broad substrate scope.