An alginate-confined peroxygenase-CLEA for styrene epoxidation

Friederike E. H. Nintzel; Yinqi Wu; Matteo Planchestainer; Martin Held; Miguel Alcalde; Frank Hollmann

doi:10.1039/D1CC01868J

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An alginate-confined peroxygenase-CLEA for styrene epoxidation†

Friederike E. H. Nintzel,

‡^a Yinqi Wu,

‡^a Matteo Planchestainer,

^b Martin Held,^b Miguel Alcalde^c and Frank Hollmann

*^a

Author affiliations

* Corresponding authors

^a Department of Biotechnology, Delft University of Technology, van der Maasweg 9, Delft, The Netherlands
E-mail: f.hollmann@tudelft.nl

^b Department of Biosystems Science and Engineering, ETH Zürich, Mattenstrasse 26, Basel 4058, Switzerland

^c Department of Biocatalysis, Institute of Catalysis and Petrochemistry (CSIC), Madrid, Spain

Abstract

Oxyfunctionalisation reactions in neat substrate still pose a challenge for biocatalysis. Here, we report an alginate-confined peroxygenase-CLEA to catalyse the enantioselective epoxidation of cis-β-methylstyrene in a solvent-free reaction system achieving turnover numbers of 96 000 for the biocatalyst and epoxide concentrations of 48 mM.

This article is part of the themed collection: Green Synthesis

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Article information

DOI: https://doi.org/10.1039/D1CC01868J
Article type: Communication
Submitted: 08 Сәу. 2021
Accepted: 07 Мам. 2021
First published: 07 Мам. 2021
This article is Open Access

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Chem. Commun., 2021,57, 5766-5769

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An alginate-confined peroxygenase-CLEA for styrene epoxidation

F. E. H. Nintzel, Y. Wu, M. Planchestainer, M. Held, M. Alcalde and F. Hollmann, Chem. Commun., 2021, 57, 5766 DOI: 10.1039/D1CC01868J

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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Chemical Communications

An alginate-confined peroxygenase-CLEA for styrene epoxidation†

Abstract

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An alginate-confined peroxygenase-CLEA for styrene epoxidation

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