Synthesis of 1′-tetrazolylmethyl-spiro[pyrrolidine-3,3′-oxindoles] via two coupled one-pot processes Ugi-azide/Pictet–Spengler and oxidative spiro-rearrangement†
Alejandro
Islas-Jácome, 
b
Luis E.
Cárdenas-Galindo,
c
M. V. Basavanag
Unnamatla
a
and
Rocío
Gámez-Montaño
*a
b
Luis E.
Cárdenas-Galindo,
c
M. V. Basavanag
Unnamatla
a
and
Rocío
Gámez-Montaño
*a
Abstract
Six novel tris-heterocycles 1′-tetrazolylmethyl-spiro[pyrrolidine-3,3′-oxindoles] were synthesized in 39–82% yields in two experimental steps: (i) a one-pot Ugi-azide/Pictet–Spengler process coupled to (ii) a one-pot oxidative spiro-rearrangement. The synthesized polyheterocycles could be used for further in vitro studies because they contain moieties present in various anticancer bioactive molecules and drugs.
![Graphical abstract: Synthesis of 1′-tetrazolylmethyl-spiro[pyrrolidine-3,3′-oxindoles] via two coupled one-pot processes Ugi-azide/Pictet–Spengler and oxidative spiro-rearrangement](/kk/Image/Get?imageInfo.ImageType=GA&imageInfo.ImageIdentifier.ManuscriptID=C7NJ03829A&imageInfo.ImageIdentifier.Year=2018)
- This article is part of the themed collection: Celebrating recent chemical science in Mexico
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