Issue 27, 2018
From the journal:

CrystEngComm

Cocrystal formation by ionic liquid-assisted grinding: case study with cocrystals of caffeine†

Arijit Mukherjee, ORCID logo a   Robin D. Rogers ORCID logo b  and  A. S. Myerson ORCID logo *a  

* Corresponding authors

a Novartis-MIT Center for Continuous Manufacturing, and Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA
E-mail: myerson@mit.edu

b 525 Solutions, Inc., P.O. Box 2206, Tuscaloosa, AL 35403, USA

Abstract

Liquid assisted grinding using imidazolium-based ionic liquids (IL-AG) was found to be effective in isolation of cocrystals and cocrystal polymorphs. Isolation of specific polymorphs of caffeine–citric acid (CAF–CA) and caffeine–glutaric acid (CAF–GLU) cocrystals highlights the tunability of ILs in polymorphic control.

Graphical abstract: Cocrystal formation by ionic liquid-assisted grinding: case study with cocrystals of caffeine

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/C8CE00859K
Article type
Communication
Submitted
23 Мам. 2018
Accepted
12 Мау. 2018
First published
20 Мау. 2018
This article is Open Access
Creative Commons BY-NC license

CrystEngComm, 2018,20, 3817-3821

Permissions

Request permissions

Cocrystal formation by ionic liquid-assisted grinding: case study with cocrystals of caffeine

A. Mukherjee, R. D. Rogers and A. S. Myerson, CrystEngComm, 2018, 20, 3817 DOI: 10.1039/C8CE00859K

This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. You can use material from this article in other publications, without requesting further permission from the RSC, provided that the correct acknowledgement is given and it is not used for commercial purposes.

To request permission to reproduce material from this article in a commercial publication, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party commercial publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements