Issue 73, 2018

Nucleophilic amination of methoxypyridines by a sodium hydride–iodide composite

Abstract

A new protocol for nucleophilic amination of methoxypyridines and their derivatives was developed using sodium hydride (NaH) in the presence of lithium iodide (LiI). The method offers a concise access to various aminopyridines which are potentially of medicinal interest.

Graphical abstract: Nucleophilic amination of methoxypyridines by a sodium hydride–iodide composite

Supplementary files

Article information

Article type
Communication
Submitted
24 Шіл. 2018
Accepted
15 Там. 2018
First published
16 Там. 2018

Chem. Commun., 2018,54, 10324-10327

Nucleophilic amination of methoxypyridines by a sodium hydride–iodide composite

J. H. Pang, A. Kaga and S. Chiba, Chem. Commun., 2018, 54, 10324 DOI: 10.1039/C8CC05979A

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