TBHP-promoted direct oxidation reaction of benzylic Csp3–H bonds to ketones

Jiajing Tan; Tianyu Zheng; Yuqi Yu; Kun Xu

doi:10.1039/C7RA00352H

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TBHP-promoted direct oxidation reaction of benzylic C_sp³–H bonds to ketones†

Jiajing Tan,

*^a Tianyu Zheng,^a Yuqi Yu^c and Kun Xu*^b

Author affiliations

* Corresponding authors

^a Department of Organic Chemistry, Faculty of Science, Beijing University of Chemical Technology, Beijing 100029, China
E-mail: tanjj@mail.buct.edu.cn

^b College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang, Henan 473061, P. R. China
E-mail: xukun@nynu.edu.cn

^c China Academy of Engineering Physics, P. O. Box 919, Mianyang, Sichuan, China

Abstract

A metal-free oxidation system employing tert-butyl hydroperoxide (TBHP) has been developed for selective oxidation of structurally diverse benzylic sp³ C–H bonds. This low-cost methodology allows for rapid generation of synthetically and biologically valued arylketones in good to excellent yields from readily available alkylarenes and diarylmethanes.

This article is part of the themed collection: Sustainable synthesis

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Article information

DOI: https://doi.org/10.1039/C7RA00352H
Article type: Paper
Submitted: 09 Қаң. 2017
Accepted: 27 Ақп. 2017
First published: 07 Нау. 2017
This article is Open Access

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RSC Adv., 2017,7, 15176-15180

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TBHP-promoted direct oxidation reaction of benzylic C_sp³–H bonds to ketones

J. Tan, T. Zheng, Y. Yu and K. Xu, RSC Adv., 2017, 7, 15176 DOI: 10.1039/C7RA00352H

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