Issue 1, 2017

A review: the trend of progress about pH probes in cell application in recent years

Abstract

Intracellular pH values are some of the most important factors that govern biological processes and the acid–base homeostasis in cells, body fluids and organs sustains the normal operations of the body. Subcellular organelles including the acidic lysosomes and the alkalescent mitochondria undergo various processes such as intracellular digestion, ATP production and apoptosis. Due to their precise imaging capabilities, fluorescent probes have attracted great attention for the illustration of pH modulated processes. Furthermore, based on the unique acidic extracellular environment of acidic lysosomes, fluorescent probes can specifically be activated in cancer cells or tumors. In this review, recently reported lysosome and mitochondria specific pH imaging probes as well as pH-activatable cancer cell-targetable probes have been discussed.

Graphical abstract: A review: the trend of progress about pH probes in cell application in recent years

Article information

Article type
Tutorial Review
Submitted
30 Там. 2016
Accepted
02 Қаз. 2016
First published
04 Қаз. 2016

Analyst, 2017,142, 30-41

A review: the trend of progress about pH probes in cell application in recent years

Y. Yue, F. Huo, S. Lee, C. Yin and J. Yoon, Analyst, 2017, 142, 30 DOI: 10.1039/C6AN01942K

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements