Issue 14, 2016

Ratiometric mechanosensitive fluorescent dyes: design and applications

Abstract

Fluorescent molecules, with their almost instantaneous response to external influences and relatively low-cost measurement instrumentation, have been attractive analytical tools and biosensors for centuries. More recently, advanced chemical synthesis and targeted design have accelerated the development of fluorescent probes. This article focuses on dyes with segmental mobility (known as fluorescent molecular rotors) that act as mechanosensors, which are known for their relationship of emission quantum yield with microviscosity. Fluorescence lifetime is directly related to quantum yield, but steady-state emission intensity is not. To remove confounding factors with steady-state instrumentation, dual-band emission dyes can be used, and molecular rotors have been developed that either have intrinsic dual emission or that have a non-sensitive reference unit to provide a calibration emission band. We report on theory, chemical structure, applications and targeted design of several classes of dual-emission molecular rotors.

Graphical abstract: Ratiometric mechanosensitive fluorescent dyes: design and applications

Article information

Article type
Review Article
Submitted
26 Қаз. 2015
Accepted
22 Жел. 2015
First published
14 Қаң. 2016

J. Mater. Chem. C, 2016,4, 2707-2718

Author version available

Ratiometric mechanosensitive fluorescent dyes: design and applications

M. A. Haidekker and E. A. Theodorakis, J. Mater. Chem. C, 2016, 4, 2707 DOI: 10.1039/C5TC03504J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements