Safe and efficient membrane permeabilizing polymers based on PLLA for antibacterial applications

Abstract

Poly(N,N-dimethylaminoethyl methacrylate)-block-poly(L-lactic acid)-block-poly(N,N-dimethylaminoethyl methacrylate) conjugated with poly(ethylene glycol) (D-PLLA-D@PEG) copolymers were synthesized. These non-aggregating polymers showed low MIC values against Gram-negative and Gram-positive, including methicillin-resistant Staphylococcus aureus (MRSA), bacteria. The polymers exhibited minimal toxicity and are promising antibacterial agents for biomedical applications.